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CDK9 Antagonist-1

CDK9 Antagonist-1 (compounds 11c) is a potent and selective PROTAC-based CDK9 degrader, demonstrating an IC50 of 17 μM in MCF-7 breast cancer cells. This compound, which utilizes a wogonin-derived linker to engage the CRBN E3 ligase, is a valuable chemical probe for investigating CDK9-dependent transcription in oncology and molecular pharmacology research.

Product Specifications

Field of Research

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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