2,3-Dehydro-3,4-dihydro ivermectin
This ivermectin analog exhibits potent antileishmanial activity against both promastigote and amastigote forms of L. amazonensis, with IC50 values of 13.8 μM and 3.6 μM, respectively. It demonstrates a favorable selectivity index due to low cytotoxicity in macrophages (IC50 = 65.5 μM), supporting its investigation for in vitro and in vivo models of leishmaniasis.
Product Specifications
CAS Number
1135339-49-9
Field of Research
Infectious Disease & Virology
Smiles
CC[C@H] (C) [C@H]1O[C@]2 (CC[C@@H]1C) C[C@@H]1C[C@@H] (C\C=C (C) \[C@@H] (O[C@H]3C[C@H] (OC) [C@@H] (O[C@H]4C[C@H] (OC) [C@H] (O) [C@H] (C) O4) [C@H] (C) O3) [C@@H] (C) \C=C\C=C3/CO[C@@H]4[C@H] (O) C (C) C=C (C (=O) O1) [C@]34O) O2
Molecular Formula
C48H74O14
Molecular Weight
875.106
Storage Conditions
-20°C
Notes
For research use only.
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