Meglutol

Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis) . Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases[1][2].

Product Specifications

CAS Number

[503-49-1]

Product Name Alternative

Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

UNSPSC

12352211

Hazard Statement

H315-H319

Target

Autophagy; Endogenous Metabolite; HMG-CoA Reductase (HMGCR)

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Meglutol.html

Concentration

10mM

Purity

98.00

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CC(C)(O)CC(O)=O

Molecular Formula

C6H10O5

Molecular Weight

162.14

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Leipnitz G, et al. Evidence that 3‐hydroxy‐3‐methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex[J]. Journal of neuroscience research, 2008, 86 (3) : 683-693.