Meglutol
Product Specifications
UNSPSC Description
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases[1][2].
Target Antigen
Autophagy; Endogenous Metabolite; HMG-CoA Reductase (HMGCR)
Type
Natural Products
Related Pathways
Autophagy;Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Meglutol.html
Purity
98.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CC(C)(O)CC(O)=O
Molecular Weight
162.14
References & Citations
[1]Leipnitz G, et al. Evidence that 3‐hydroxy‐3‐methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex[J]. Journal of neuroscience research, 2008, 86(3): 683-693.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1189/Meglutol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1189/Meglutol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
503-49-1
Available Sizes
Curated Selection
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