PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13 is a potent heterobifunctional degrader that effectively targets BRD4 for proteasomal degradation, particularly in PC3 prostate cancer cells. Its activity is significantly enhanced when conjugated to STEAP1 or CLL1 antibodies, achieving DC50 values as low as 0.025 nM. This compound is a valuable tool for investigating BRD4 biology and targeted protein degradation in cancer research.
Product Specifications
CAS Number
2417370-71-7
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@H] (CN2C (=O) [C@@H] (NC (=O) CCCCCCCCCCNC (=O) c2cc3N (Cc4c[nH]c5c4c (cn (C) c5=O) -c3cc2CS (C) (=O) =O) c2ncc (F) cc2F) C (C) (C) C) OP (O) (=O) OP (O) (=O) OCCNC (=O) CCCCCN2C (=O) C=CC2=O) cc1 |c:103|
Molecular Formula
C68H85F2N11O17P2S2
Molecular Weight
1492.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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