BMS-1166-N-piperidine-CO-N-piperazine
BMS-1166-N-piperidine-CO-N-piperazine is a bifunctional molecule incorporating a PD-1/PD-L1 inhibitor linked to a PROTAC moiety. It serves as a key intermediate for synthesizing PROTAC PD-1/PD-L1 degrader-1, a compound which disrupts the PD-1/PD-L1 interaction with an IC50 of 39.2 nM in biochemical assays. This tool compound is designed for research into targeted protein degradation within cancer immunology.
Product Specifications
CAS Number
2447066-14-8
Field of Research
Pharmacology & Drug Discovery
Smiles
Cc1c (COc2cc (OCc3cccc (c3) C#N) c (CN3CCCCC3C (=O) N3CCNCC3) cc2Cl) cccc1-c1ccc2OCCOc2c1
Molecular Formula
C41H43ClN4O5
Molecular Weight
707.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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