PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a highly potent and selective degrader of IRAK3, demonstrating an IC50 of 5 nM. This tool compound enables the investigation of IRAK3's role in innate immunity and inflammatory signaling pathways in both cellular and animal models of disease.
Product Specifications
CAS Number
2712600-00-3
Field of Research
Pharmacology & Drug Discovery
Smiles
CC (C) c1ccn2ncnc (N[C@H]3CC[C@H] (CC3) N3CCN (CC3) C (=O) CCC (=O) N3CCC (CCN4CCN (CC4) c4ccc5C (=O) N (C6CCC (=O) NC6=O) C (=O) c5c4) CC3) c12 |wU:15.18,12.11, (-.91, -3.09, ; -1.94, -1.94, ; -3.45, -2.26, ; -1.46, -.48, ; -2.37, .77, ; -1.46,2.02, ; ,1.54, ;1.33,2.31, ;2.67,1.54, ;2.67, , ;1.33, -.77, ;1.33, -2.31, ;2.67, -3.08, ;4, -2.31, ;5.33, -3.08, ;5.33, -4.62, ;4, -5.39, ;2.67, -4.62, ;6.67, -5.39, ;6.67, -6.93, ;8, -7.7, ;9.34, -6.93, ;9.34, -5.39, ;8, -4.62, ;10.67, -7.7, ;10.67, -9.24, ;12, -6.93, ;13.34, -7.7, ;14.67, -6.93, ;14.67, -5.39, ;16, -7.7, ;16, -9.24, ;17.34, -10.01, ;18.67, -9.24, ;20.01, -10.01, ;21.34, -9.24, ;22.67, -10.01, ;22.67, -11.55, ;24.01, -12.32, ;25.34, -11.55, ;25.34, -10.01, ;24.01, -9.24, ;26.67, -12.32, ;26.67, -13.86, ;28.01, -14.63, ;29.34, -13.86, ;30.81, -14.34, ;31.28, -15.8, ;31.71, -13.09, ;33.25, -13.09, ;34.02, -14.42, ;35.56, -14.42, ;36.33, -13.09, ;37.87, -13.09, ;35.56, -11.76, ;34.02, -11.76, ;33.25, -10.42, ;30.81, -11.84, ;31.28, -10.38, ;29.34, -12.32, ;28.01, -11.55, ;18.67, -7.7, ;17.34, -6.93, ; ) |
Molecular Formula
C47H63N11O6
Molecular Weight
878.092
Storage Conditions
-20°C
Notes
For research use only.
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