YKL-5-124 TFA
YKL-5-124 TFA is a highly selective, irreversible covalent inhibitor of CDK7, demonstrating potent activity against both isolated CDK7 and the CDK7/Mat1/CycH complex. It induces cell-cycle arrest and suppresses E2F-driven transcription in vitro, making it a valuable chemical probe for studying transcriptional regulation and cell-cycle control in cancer research.
Product Specifications
CAS Number
2748220-93-9
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
C (C (O) =O) (F) (F) F.N (C (=O) C1=CC=C (NC (C=C) =O) C=C1) C=2C3=C (C (C) (C) N (C (N[C@H] (CN (C) C) C4=CC=CC=C4) =O) C3) NN2
Molecular Formula
C30H34F3N7O5
Molecular Weight
629.63
Storage Conditions
-20°C
Notes
For research use only.
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