SR 142948 dihydrochloride

SR 142948 dihydrochloride is a potent, brain-penetrant, and selective non-peptide antagonist of the neurotensin receptor (NTR1) . It effectively blocks neurotensin-mediated signaling in cellular assays (e.g., inositol monophosphate formation in HT-29 cells) and inhibits NT-induced behavioral responses like hypothermia and analgesia in vivo, making it a valuable research tool for studying psychiatric and neurological disorders.