Leriglitazone hydrochloride

Leriglitazone hydrochloride is a metabolite of pioglitazone that functions as a PPARγ agonist, stabilizing the AF-2 surface to enhance co-activator recruitment with a K i of 1.2 μM and an EC 50 of 680 nM. This compound is a valuable research tool for studying PPARγ-mediated transcriptional regulation in metabolic and inflammatory disease models, both in vitro and in vivo.