Abemaciclib metabolite M18
M18 (LSN3106729), an active metabolite of abemaciclib, is a potent CDK4/6 inhibitor. It has been utilized as a warhead in the design of CRBN-based PROTAC molecules, enabling targeted degradation of CDK4/6 proteins for research in oncology and cellular proliferation studies.
Product Specifications
CAS Number
2704316-81-2
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C (C) (C) N1C=2C (N=C1CO) =C (F) C=C (C2) C3=NC (NC4=CC=C (CN5CCNCC5) C=N4) =NC=C3F
Molecular Formula
C25H28F2N8O
Molecular Weight
494.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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