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Ep300/CREBBP-IN-8

Ep300/CREBBP-IN-8 (Example 37) is a potent, orally bioavailable dual inhibitor of the histone acetyltransferases EP300 and CREBBP, with IC50 values of 14 nM and 18 nM, respectively. It is a valuable chemical probe for oncology research, enabling the study of epigenetic mechanisms in both cellular and animal models of cancer.

Product Specifications

CAS Number

2259641-24-0

Field of Research

Epigenetics & Chromatin, Signal Transduction

Smiles

COc1ccc (cc1F) C1 (CCCCC1) C (=O) N1C[C@H] (F) C[C@@H]1C (=O) Nc1ccc2[nH]ncc2n1

Molecular Formula

C25H27F2N5O3

Molecular Weight

483.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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