Pyridinium bisretinoid A2E
Pyridinium bisretinoid A2E is a lipophilic cationic fluorophore and weak photosensitizer derived from retinal pigment epithelium lipofuscin. Its blue light-induced cytotoxicity, which promotes apoptosis and autophagy while disrupting membrane integrity, makes it a critical tool for studying retinal degeneration in models of age-related macular degeneration (AMD) both in vitro and in vivo.
Product Specifications
CAS Number
173449-96-2
Product Name Alternative
A2E
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
83.65% (May vary between batches)
Solubility
DMSO:120 mg/mL (202.39 mM)
Smiles
C (CO) [N+]=1C (/C=C (/C=C/C=C (/C=C/C=2C (C) (C) CCCC2C) \C) \C) =CC (/C=C/C=C (/C=C/C=3C (C) (C) CCCC3C) \C) =CC1
Molecular Formula
C42H58NO
Molecular Weight
592.92
Storage Conditions
-20°C
Notes
For research use only.
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