PROTAC-O4I2
PROTAC-O4I2 is a heterobifunctional degrader that targets the splicing factor SF3B1, inducing its degradation with an IC50 of 0.244 μM in K562 cells and triggering apoptosis. This molecule serves as a valuable chemical probe for studying RNA splicing mechanisms and cancer cell survival in leukemia research models.
Product Specifications
CAS Number
2785323-62-6
Product Name Alternative
Apoptosis, PROTAC
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
96.31% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.21 mM) ; DMSO:200 mg/mL (328.35 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCCCCCNC (=O) C=4N=C (NC5=CC=C (Cl) C=C5) SC4
Molecular Formula
C29H29ClN6O5S
Molecular Weight
609.1
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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