GSK_WRN2
GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA) n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk-wrn2.html
Purity
95.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC(C#CCNC(C1=CC=C(NC1=O)C2=CC=CC=C2)=O)=O
Molecular Formula
C17H15N3O3
Molecular Weight
309.32
References & Citations
[1]Picco, et al. "Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells." Cancer Discovery 14.8 (2024) : 1457-1475.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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