HL-8
HL-8 is a potent PROTAC that induces complete degradation of PI3K at 10 μM within 8 hours. This mechanism demonstrates utility for probing PI3K-dependent signaling pathways in cancer research, supporting both in vitro cellular studies and in vivo preclinical investigations.
Product Specifications
CAS Number
2766352-64-9
Field of Research
Signal Transduction
Smiles
COc1ncc (cc1NS (=O) (=O) c1ccc (F) cc1F) -c1ccc2ncc (-c3nnc (o3) -c3ccccc3C (=O) NCCCCCCC (=O) N[C@H] (C (=O) N3C[C@@H] (O) C[C@@H]3C (=O) NCc3ccc (cc3) -c3scnc3C) C (C) (C) C) n2c1
Molecular Formula
C57H59F2N11O9S2
Molecular Weight
1144.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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