MS143
MS143 is a potent and selective AKT degrader with a DC50 of 46 nM in PC3 cells. It induces targeted protein degradation via the ubiquitin-proteasome system, suppressing cancer cell proliferation in vitro. This molecule is a valuable chemical probe for studying AKT-dependent signaling pathways in oncology research.
Product Specifications
CAS Number
2376137-41-4
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCCCCCCCCCC (=O) N2CCN (CC[C@H] (NC (=O) C3 (N) CCN (CC3) c3ncnc4[nH]ccc34) c3ccc (Cl) cc3) CC2) C (C) (C) C) cc1
Molecular Formula
C59H81ClN12O6S
Molecular Weight
1121.87
Storage Conditions
-20°C
Notes
For research use only.
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