PSI-353661
PSI-353661 (GS-558093) is a potent purine nucleotide analog inhibitor targeting the HCV NS5B polymerase. It demonstrates low nanomolar efficacy against both wild-type and S282T-resistant HCV replicons in vitro, supported by efficient intracellular conversion to its active triphosphate form in primary human hepatocytes, making it a valuable tool for antiviral mechanism and resistance studies.
Product Specifications
CAS Number
1231747-08-2
Field of Research
Infectious Disease & Virology, Protein Biochemistry
Smiles
COc1nc (N) nc2n (cnc12) [C@@H]1O[C@H] (COP (=O) (N[C@@H] (C) C (=O) OC (C) C) Oc2ccccc2) [C@@H] (O) [C@@]1 (C) F
Molecular Formula
C24H32FN6O8P
Molecular Weight
582.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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