YF135
YF135 is a reversible-covalent KRAS G12C PROTAC that degrades the oncogenic protein via VHL E3 ligase recruitment and proteasomal destruction, leading to reduced phospho-ERK signaling. This bifunctional molecule, derived from MRTX849 and a VHL ligand, is a valuable chemical tool for investigating KRAS-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
2913177-53-2
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCOCCCN2CCC[C@H]2COc2nc3CN (CCc3c (n2) N2CCN ([C@@H] (CC#N) C2) C (=O) C (=C\C2CC2) \C#N) c2cccc3cccc (Cl) c23) C (C) (C) C) cc1
Molecular Formula
C63H75ClN12O7S
Molecular Weight
1179.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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