PROTAC SOS1 degrader-2
PROTAC SOS1 degrader-2 is a potent and selective degrader of SOS1, leading to dose-dependent reductions in pERK and RAS-GTP levels. It demonstrates robust anti-tumor efficacy in vivo, making it a valuable chemical probe for researching RAS-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
2913176-81-3
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C[C@H] (NC (=O) [C@@H]1C[C@H] (O) CN1C (=O) [C@@H] (NC (=O) CCCCCCCCN1CCN (CC1) c1cc (Cl) cc2n (Cc3cc (C) c (F) c (C) c3) c (nc12) N1CC2 (CNC2) C1) C (C) (C) C) c1ccc (cc1) -c1scnc1C
Molecular Formula
C57H76ClFN10O4S
Molecular Weight
1051.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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