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XY-06-007

XY-06-007 is a potent and selective bump-and-hole PROTAC designed to degrade the BRD4 BD1 L94V mutant with a DC50 of 10 nM at 6 hours, showing minimal off-target activity. Its favorable pharmacokinetic profile supports its use for probing BET bromodomain function in both cellular and animal models of cancer and transcriptional regulation.

Product Specifications

CAS Number

2757045-94-4

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Smiles

[H][C@]1 (N=C (c2ccc (Cl) cc2) c2cc (OC) ccc2-n2c (C) nnc12) [C@@H] (C) C (=O) NCCCCCNC (=O) COc1cccc2C (=O) N (C3CCC (=O) NC3=O) C (=O) c12

Molecular Formula

C41H41ClN8O8

Molecular Weight

809.27

Storage Conditions

-20°C

Notes

For research use only.

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