Tri (TLR4-IN-C34-C2-amide-C3-amide-PEG1) -amide-C3-COOH

This small molecule linker incorporates the TLR4 inhibitor TLR4-IN-C34. It effectively suppresses TLR4 signaling in both enterocytes and macrophages, demonstrating efficacy in reducing systemic inflammation in murine models of endotoxemia and necrotizing enterocolitis, making it a valuable research tool for studying innate immunity and inflammatory pathways.