PROTAC AR-V7 degrader-1

Compound 6 is an orally active PROTAC that selectively degrades the androgen receptor splice variant AR-V7 via VHL recruitment, with a DC50 of 0.32 μM. It is a valuable research tool for studying castration-resistant prostate cancer models, demonstrating cellular efficacy in AR-V7-expressing 22Rv1 cells (EC50 = 0.88 μM) .

Product Specifications

CAS Number

2767440-24-2

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

C ([C@@H] (NC (CCCCOC1=CC=C (C=C1) C=2N=C (SC2) N3CCOCC3) =O) [C@@] (C) (C) C) (=O) N4[C@H] (C (N[C@@H] (C) C5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4