KT-474
KT-474 (KYM-001) is a PROTAC molecule designed to degrade IRAK4, a key kinase in innate immune signaling. Its application is primarily in preclinical research for autoimmune, inflammatory, and oncological diseases, with studies demonstrating its activity in both cellular assays and animal models of inflammation.
Product Specifications
CAS Number
2432994-31-3
Product Name Alternative
KYM001, KYM-001, KT474, PROTAC, PROTAC IRAK4 degrader-7
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.50% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (3.81 mM) ; DMSO:80 mg/mL (92.39 mM)
Smiles
O=C1N (C=2C (=C (C#CCOC3CCN (C[C@H]4CC[C@@H] (CC4) N5C=C (NC (=O) C6=C7N (N=C6) C=CC (=N7) N8[C@@]9 (C[C@] (C8) (OC9) [H]) [H]) C (C (F) F) =N5) CC3) C=CC2) N1C) C%10C (=O) NC (=O) CC%10
Molecular Formula
C44H49F2N11O6
Molecular Weight
865.93
Storage Conditions
-20°C
Notes
For research use only.
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