β-Glucuronide-dPBD-PEG5-NH2 TFA
This β-glucuronide-conjugated pyrrolobenzodiazepine (PBD) dimer is a proagent designed for constructing antibody-drug conjugates (ADCs) with a cleavable linker. It functions as a potent cytotoxin, inducing apoptosis and cell cycle arrest in tumor cells, and its application is primarily in ADC research for targeted cancer therapy in both in vitro and in vivo models.
Product Specifications
CAS Number
2246364-63-4
Field of Research
Cell Biology, Immunology & Inflammation; Stem Cell & Developmental Biology
Smiles
OC (=O) C (F) (F) F.[H][C@@]12CC (=C) CN1C (=O) c1cc (OC) c (OCCCCCOc3cc4N (C (O) [C@]5 ([H]) CC (=C) CN5C (=O) c4cc3OC) C (=O) OCc3ccc (O[C@@H]4O[C@@H] ([C@@H] (O) [C@H] (O) [C@H]4O) C (O) =O) c (c3) C (=O) NCCOCCOCCOCCOCCOCCON) cc1N (C2O) C (=O) OCc1ccc (O[C@@H]2O[C@@H] ([C@@H] (O) [C@H] (O) [C@H]2O) C (O) =O) c (c1) C (=O) NCCOC
Molecular Formula
C80H102F3N7O37
Molecular Weight
1810.69
Storage Conditions
-20°C
Notes
For research use only.
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