PROTAC SOS1 degrader-1
PROTAC SOS1 degrader-1 is a potent small molecule that effectively degrades SOS1 with a DC50 of 98.4 nM. It demonstrates antiproliferative activity against various KRAS-mutant cancer cell lines in vitro and has shown in vivo antitumor efficacy with a favorable toxicity profile, supporting its use in oncology research.
Product Specifications
CAS Number
2913185-35-8
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
Cc1cc (Cn2c (N3CC4 (CNC4) C3) nc3c (N4CCN (CCCCCCCCC (=O) N[C@H] (C (=O) N5C[C@H] (O) C[C@H]5C (=O) N[C@@H] (C) c5ccc (-c6scnc6C) cc5) C (C) (C) C) CC4) cc (Cl) cc32) cc (C) c1F
Molecular Formula
C57H76O4ClFN10S
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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