JPS014
JPS014 is a benzamide-based PROTAC that recruits the VHL E3 ligase to selectively degrade HDAC1/2. This degradation alters gene expression and induces apoptosis in HCT116 cells, making it a valuable tool for studying HDAC biology and targeted protein degradation in cancer research models.
Product Specifications
CAS Number
2669785-76-4
Field of Research
Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCCCCCCCOCC (=O) Nc2ccc (cc2) C (=O) Nc2ccccc2N) C (C) (C) C) cc1
Molecular Formula
C46H59N7O7S
Molecular Weight
854.07
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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