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PROTAC EGFR degrader 4

PROTAC EGFR degrader 4 potently induces degradation of mutant EGFR variants, including del19 and L858R/T790M, with low nanomolar DC50 values. It demonstrates strong anti-proliferative effects in corresponding NSCLC cell lines, and its mechanism is linked to autophagy, making it a valuable tool for targeted protein degradation research in oncology.

Product Specifications

CAS Number

2882845-50-1

Field of Research

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Smiles

Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCCCCCN2CCN (CC2) c2ccc (Nc3ncc4nc (Nc5ccccc5) n (C5CCCC5) c4n3) cc2) C (C) (C) C) cc1

Molecular Formula

C55H70N12O4S

Molecular Weight

995.29

Storage Conditions

-20°C

Notes

For research use only.

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