PROTAC CYP1B1 degrader-1
Compound 6C (PROTAC CYP1B1 Degrader-1) is a potent and selective degrader of cytochrome P450 1B1, with an IC50 of 95.1 nM, demonstrating over 100-fold selectivity against CYP1A2. This α-naphthoflavone-based chimera is a valuable chemical tool for in vitro and in vivo research into overcoming drug resistance in prostate cancer models characterized by CYP1B1 overexpression.
Product Specifications
CAS Number
2411389-67-6
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
COc1ccc (OC) c2c1c (OC) cc1c2oc (cc1=O) -c1ccc (cc1) -c1cn (CCCCCCOc2cccc3C (=O) N (C4CCC (=O) NC4=O) C (=O) c23) nn1
Molecular Formula
C43H39N5O10
Molecular Weight
785.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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