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PROTAC CYP1B1 degrader-1

Compound 6C (PROTAC CYP1B1 Degrader-1) is a potent and selective degrader of cytochrome P450 1B1, with an IC50 of 95.1 nM, demonstrating over 100-fold selectivity against CYP1A2. This α-naphthoflavone-based chimera is a valuable chemical tool for in vitro and in vivo research into overcoming drug resistance in prostate cancer models characterized by CYP1B1 overexpression.

Product Specifications

CAS Number

2411389-67-6

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

COc1ccc (OC) c2c1c (OC) cc1c2oc (cc1=O) -c1ccc (cc1) -c1cn (CCCCCCOc2cccc3C (=O) N (C4CCC (=O) NC4=O) C (=O) c23) nn1

Molecular Formula

C43H39N5O10

Molecular Weight

785.8

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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