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Bromoenol lactone

Bromoenol lactone ((6E) -Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].

Product Specifications

CAS Number

88070-98-8

Product Name Alternative

(6E) -Bromoenol lactone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bromoenol-lactone.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br

Molecular Formula

C16H13BrO2

Molecular Weight

317.18

Precautions

H315, H319, H335

References & Citations

[1]Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41 (2) :145-53.|[2]Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121 (6) :1018-24.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Phospholipase A

Available Sizes

Frequently Asked Questions

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