JBJ-09-063 TFA

JBJ-09-063 TFA is a potent, mutant-selective allosteric EGFR inhibitor effective against various EGFR mutations, including L858R and T790M/C797S. It suppresses downstream signaling pathways and has shown efficacy in both EGFR TKI-sensitive and resistant models, making it a valuable compound for lung cancer research.