SJ1008030
SJ1008030 (compound 8) is a potent and selective JAK2 PROTAC degrader. It exhibits strong anti-proliferative activity in MHH–CALL-4 leukemia cells (EC50 5.4 nM; IC50 32.09 nM), supporting its utility as a chemical probe for hematological cancer research.
Product Specifications
CAS Number
2863634-96-0
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CCS (=O) (=O) N1CC (CC#N) (C1) n1cc (cn1) -c1nc (Nc2ccc (cc2) C (=O) NCCN2CCN (CC2) c2ccc3C (=O) N (C4CCC (=O) NC4=O) C (=O) c3c2) nc2[nH]ccc12
Molecular Formula
C42H43N13O7S
Molecular Weight
873.94
Storage Conditions
-20°C
Notes
For research use only.
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