PROTAC EGFR degrader 7

PROTAC EGFR degrader 7 is a potent and selective CRBN-based degrader of EGFR L858R/T790M mutants, demonstrating a DC50 of 13.2 nM. It inhibits proliferation (IC50=46.82 nM), induces apoptosis and G2/M arrest in NCI-H1975 cells, showing promise for targeted NSCLC research both in vitro and in vivo.