MS9427 TFA

MS9427 TFA is a potent and selective PROTAC degrader of mutant EGFR (L858R), with high affinity for both wild-type (Kd=7.1 nM) and mutant (Kd=4.3 nM) forms. It induces degradation via UPS and autophagy pathways, demonstrating efficacy in inhibiting NSCLC cell proliferation in vitro, supporting its use in targeted cancer therapy research.