MS9449
MS9449 is a potent PROTAC degrader of wild-type and L858R mutant EGFR, with Kd values of 17 nM and 10 nM, respectively. It induces degradation via both the proteasome and autophagy pathways, demonstrating robust anti-proliferative activity in NSCLC cell models, which supports its utility in targeted cancer therapy research.
Product Specifications
CAS Number
2772612-96-9
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
N (C=1C2=C (C=C (OC) C (OCCCN3CCN (C (CCCCCCCCCCNC (C[C@H] (NC (=O) [C@H]4N (C ([C@H] ([C@H] (C) C) C=5ON=C (C) C5) =O) C[C@H] (O) C4) C6=CC=C (C=C6) C7=C (C) N=CS7) =O) =O) CC3) =C2) N=CN1) C8=CC (Cl) =C (F) C=C8
Molecular Formula
C60H76ClFN10O8S
Molecular Weight
1151.82
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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