XL01126
XL01126 is a potent, brain-penetrant LRRK2 degrader with DC50 values of 14 nM (G2019S) and 32 nM (WT) . It serves as a critical research probe for investigating LRRK2's scaffolding functions in Parkinson's disease models, enabling both in vitro mechanistic studies and in vivo target validation.
Product Specifications
CAS Number
3011029-58-3
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (=O) C1 (F) CC1) C (SC[C@H]2CC[C@H] (CN3CCN (C (=O) C4=CC (OC) =C (NC=5N=C (NC) C (Cl) =CN5) C=C4) CC3) CC2) (C) C) (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6
Molecular Formula
C50H64ClFN10O6S2
Molecular Weight
1019.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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