RSS0680

RSS0680 is a proteolysis-targeting chimera (PROTAC) that induces the degradation of multiple protein kinases. It serves as a valuable chemical probe for investigating kinase-driven pathologies in both cellular and animal models of disease.

Product Specifications

CAS Number

2769753-48-0

Product Name Alternative

AP2 associated kinase 1, AP2associatedkinase1, AAK1, AAK1 (AP2 associated kinase 1), AAK1 (AP2associatedkinase1), CDK, PROTAC, SIK

Field of Research

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Purity

99.85% (May vary between batches)

Solubility

DMSO:80 mg/mL (78.33 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.9 mM)

Smiles

N (C=1N=C2C (=CSC2=CN1) C3=CC (NS (C) (=O) =O) =CC=C3) C4=CC=C (C=C4) N5CCN (CCCCCC (N[C@H] (C (=O) N6[C@H] (C (N[C@@H] (C) C7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) [C@@] (C) (C) C) =O) CC5