SR140333B
SR140333B is a selective NK1 receptor inhibitor that can reduce LPS-induced fever and mitigate LPS -induced changes in brain tissue in rats[1].
Product Specifications
CAS Number
155418-06-7
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sr140333b.html
Smiles
ClC1=CC=C(C=C1Cl)[C@@]2(CN(C(CC3=CC=CC(OC(C)C)=C3)=O)CCC2)CC[N+]4(CC5)CCC5(CC4)C6=CC=CC=C6.[O-]S(C7=CC=CC=C7)(=O)=O
Molecular Formula
C43H50Cl2N2O5S
Molecular Weight
777.84
References & Citations
[1]Brito H O, et al. NK1 receptor mediates cerebral cellular and extracellular morphological changes during the LPS-induced febrile response[J]. Brain Research, 2024: 149107.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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