JPE-1375
JPE-1375 is a potent and selective C5aR1 antagonist, with in vivo studies demonstrating its efficacy in inhibiting neutrophil mobilization (EC50=6.9 μM) and reducing TNF-α levels (EC50=4.5 μM) in mice. This makes it a valuable research tool for investigating the complement system in autoimmune and inflammatory disease models.
Product Specifications
CAS Number
1254036-23-1
Field of Research
Immunology & Inflammation
Smiles
C ([C@@H] (NC ([C@H] (CC1=CC=CC=C1) NC (=O) [C@@H]2CC (=O) NC (=O) N2) =O) CCCN) (=O) N3[C@H] (C (N[C@H] (C (N[C@@H] (CC4=CC=C (F) C=C4) C (N[C@@H] (CC5=CC=CC=C5) C (N) =O) =O) =O) CCC (C) C) =O) CCC3
Molecular Formula
C49H63FN10O9
Molecular Weight
955.08
Storage Conditions
-20°C
Notes
For research use only.
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