KTX-582
KTX-582 is a potent and selective degrader of IRAK4 and Ikaros, with DC50 values in the low nanomolar range. It effectively triggers apoptosis in MYD88-mutant DLBCL models and has shown promising activity in inducing tumor regression in vivo, supporting its investigation in lymphoma research.
Product Specifications
CAS Number
2573298-13-0
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CN (CCCO[C@H]1C[C@@H] (C1) Nc1cccc2C (=O) N (C3CCC (=O) NC3=O) C (=O) c12) C[C@H]1CC[C@@H] (CC1) n1cc2cc (NC (=O) c3cccc (n3) C (F) (F) F) c (cc2n1) C (C) (C) O
Molecular Formula
C45H51F3N8O7
Molecular Weight
872.93
Storage Conditions
-20°C
Notes
For research use only.
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