NecroIr2
NecroIr2 is an iridium (III) complex that induces necroptosis in cisplatin-resistant A549R lung cancer cells. It localizes to mitochondria, triggering oxidative stress, loss of MMP, and activation of the RIPK3/MLKL pathway while modulating CDK4 expression, making it a useful research tool for studying programmed necrosis in drug-resistant cancers.
Product Specifications
Field of Research
Cell Biology, Signal Transduction
Molecular Formula
C46H30ClIrN6O2-
Molecular Weight
926.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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