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NecroIr2

NecroIr2 is an iridium (III) complex that induces necroptosis in cisplatin-resistant A549R lung cancer cells. It localizes to mitochondria, triggering oxidative stress, loss of MMP, and activation of the RIPK3/MLKL pathway while modulating CDK4 expression, making it a useful research tool for studying programmed necrosis in drug-resistant cancers.

Product Specifications

Field of Research

Cell Biology, Signal Transduction

Molecular Formula

C46H30ClIrN6O2-

Molecular Weight

926.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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