A947
A947 is a potent and selective SMARCA2 PROTAC degrader that recruits the VHL E3 ligase. It demonstrates significant antitumor activity in both cellular and animal models, particularly in SMARCA4-mutant NSCLC, supporting its use in oncology and targeted protein degradation research.
Product Specifications
CAS Number
2378056-80-3
Product Name Alternative
A 947
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
98.84% (May vary between batches)
Smiles
O (C1=CC (N2C3CN (CC2CC3) C=4C=C (N=NC4N) C5=C (O) C=CC=C5) =CC=N1) [C@H]6C[C@H] (OC7CCN (CC8CCN (CC8) C=9C=C ([C@H] (C (=O) N%10[C@H] (C (N[C@@H] (C) C%11=CC=C (C=C%11) C=%12SC=NC%12C) =O) C[C@@H] (O) C%10) C (C) C) ON9) CC7) C6
Molecular Formula
C61H76N12O7S
Molecular Weight
1121.4
Storage Conditions
-20°C
Notes
For research use only.
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