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YX-2-107

YX-2-107 is a potent and selective CDK6-targeting PROTAC degrader (IC50 = 4.4 nM) . It demonstrates efficacy in vitro by suppressing RB phosphorylation and FOXM1, and inhibits Ph+ ALL progression in rat models, supporting its research application for this leukemia type.

Product Specifications

CAS Number

2417408-46-7

Product Name Alternative

CDK6

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

98.09% (May vary between batches)

Solubility

DMSO:2.4 mg/mL (2.7 mM)

Smiles

O=C1NC (=O) C (N2C (=O) C=3C=CC=C (OCC (=O) NCCCCNCC (=O) N4CCN (C5=CN=C (C=C5) NC=6N=CC7=C (N6) N (C (=O) C (C (=O) C) =C7C) C8CCCC8) CC4) C3C2=O) CC1

Molecular Formula

C45H51N11O9

Molecular Weight

889.95

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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