YX-2-107
YX-2-107 is a potent and selective CDK6-targeting PROTAC degrader (IC50 = 4.4 nM) . It demonstrates efficacy in vitro by suppressing RB phosphorylation and FOXM1, and inhibits Ph+ ALL progression in rat models, supporting its research application for this leukemia type.
Product Specifications
CAS Number
2417408-46-7
Product Name Alternative
CDK6
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.09% (May vary between batches)
Solubility
DMSO:2.4 mg/mL (2.7 mM)
Smiles
O=C1NC (=O) C (N2C (=O) C=3C=CC=C (OCC (=O) NCCCCNCC (=O) N4CCN (C5=CN=C (C=C5) NC=6N=CC7=C (N6) N (C (=O) C (C (=O) C) =C7C) C8CCCC8) CC4) C3C2=O) CC1
Molecular Formula
C45H51N11O9
Molecular Weight
889.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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