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Gly-Cyclopropane-Exatecan

Gly-Cyclopropane-Exatecan is a DNA topoisomerase I inhibitor payload used to synthesize the anti-B7-H4 antibody-drug conjugate (ADC) hu2F7-Exatecan. This ADC has demonstrated potent antitumor efficacy in both in vitro and in vivo preclinical studies.

Product Specifications

CAS Number

2414254-49-0

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Smiles

CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cc (F) c (C) c5CC[C@H] (NC (=O) C (OCNC (=O) CN) C6CC6) c (c3Cn1c2=O) c45

Molecular Formula

C32H34FN5O7

Molecular Weight

619.64

Storage Conditions

-20°C

Notes

For research use only.

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