Gly-Cyclopropane-Exatecan
Gly-Cyclopropane-Exatecan is a DNA topoisomerase I inhibitor payload used to synthesize the anti-B7-H4 antibody-drug conjugate (ADC) hu2F7-Exatecan. This ADC has demonstrated potent antitumor efficacy in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
2414254-49-0
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Smiles
CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cc (F) c (C) c5CC[C@H] (NC (=O) C (OCNC (=O) CN) C6CC6) c (c3Cn1c2=O) c45
Molecular Formula
C32H34FN5O7
Molecular Weight
619.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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