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JNJ-28583113

JNJ-28583113 is a brain-penetrant TRPM2 antagonist that promotes GSK3α/β phosphorylation, conferring protection against oxidative stress-induced cell death. It suppresses pro-inflammatory microglial activation, making it a valuable tool for in vitro and in vivo research in neurodegenerative and neuroinflammatory disease models.

Product Specifications

CAS Number

2765255-93-2

Product Name Alternative

JNJ28583113

Field of Research

Pharmacology & Drug Discovery

Purity

98.57% (May vary between batches)

Solubility

DMSO:80 mg/mL (218.35 mM)

Smiles

O=C (OCC) CN1N=C (C=2C=CC (=CC2) C (F) (F) F) C3=C1CCCCC3

Molecular Formula

C19H21F3N2O2

Molecular Weight

366.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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