PROTAC GPX4 degrader-1
PROTAC GPX4 Degrader-1 (DC-2) is a potent and selective degrader of glutathione peroxidase 4 (GPX4), achieving a DC50 of 30 nM in HT1080 cells. This compound is a valuable chemical tool for investigating ferroptosis and GPX4 biology in both cellular and in vivo research contexts.
Product Specifications
CAS Number
2916433-81-1
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C1C2=C (NCCCN3CCN (CC3) CC4CCN (CC4) C (COC5=CC=C (C=C5) C (C6=CC=C (C=C6) Cl) N7CCN (CC7) C (C8=NOC (C) =C8[N+] ([O-]) =O) =O) =O) C=CC=C2C (N1C9C (NC (CC9) =O) =O) =O
Molecular Formula
C50H57ClN10O10
Molecular Weight
993.5
Storage Conditions
-20°C
Notes
For research use only.
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