YL5084
YL5084 is a covalent inhibitor with high selectivity for JNK2 (IC50 = 70 nM) and JNK3 (IC50 = 84 nM) over JNK1. It exhibits antiproliferative and pro-apoptotic activities in cellular models, which are reported to be independent of its JNK2 inhibitory function, making it a useful research tool for studying JNK isoform-specific signaling.
Product Specifications
CAS Number
2440199-73-3
Field of Research
Cell Biology, Signal Transduction
Smiles
N (C=1N=C (C=2C (=NN3C2C=CC=C3) C4=CC=CC=C4) C=CN1) [C@@H]5CN (C (=O) C6=CC=C (NC (/C=C/CN (C) C) =O) C=C6) C[C@@H]5C
Molecular Formula
C35H36N8O2
Molecular Weight
600.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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